Variaciones en el número de células neuroendócrinas de la mucosa intestinal en un modelo experimental de inmunodeficiencia por déficit proteico severo al destete

LILIANA VAUTHAY; M.GABRIELA MÁRQUEZ; NORA H.SLOBODIANIK; YOLANDA BONAPARTE; M ESTELA ROUX

Inmunología (España)

Ediciones Doyma

Lugar: Barcelona; Año: 1995 vol. 14 p. 173 - 175

0213-540X

In previous works with Wistar rats it was demostrated that severe protein deprivation at weaning even after refeeding with a 20% casein diet for 21 days, provokes alterations in IgA+ B and T cell populations from gut and GALT(gut associated lymphoid tissue) that are reverted by immunomodulator IM-104 (Inmunol.,1993,12:59-63). In the present report we investigate the influence of RN-301 (quite similar to IM-104) given by the oral or subcutaneous route, in the seeding of BALT with IgA+ B and CD5+T cells. The immunomodulator RN-301 contains LPS from Escherichia coli and membrane and ribosomal fractions of Propionibacterium acne (Neomar SRL). Tissue sections of the lower respiratory tract were studied by immunohistochemistry. The immunomodulator RN-301 administered by the oral route favours the significative increase in the seeding of the BALT lamina propria with IgA+B and CD5+T cells (RN-R21 vs R21, p