Bioinorganic Chemistry of Parkinson's Disease: Copper and something else

GARRO, HUGO A.

CABA

Simposio; Humboldt Colloquium "Shaping the Future of German-Argentinian ScientificScientific Cooperation ?The Role of Curiosity-Driven Research?; 2018

Alexander von Humboldt Foundation

Protein metal interactions play an important role in AS aggregation and might link the pathological processes of protein aggregation, oxidative damage and neuronal cell toxicity. Advances in the Bioinorganic Chemistry of Parkinsons disease require that details of the binding specificity of Cu(I) the protein a-synuclein and its conformational consequences to be better understood. In this work we have elucidated identity of the Cu(I) binding ligands at the Met-X3-Met Motif of AcAS and its role into the affinity and structural properties of the interaction. Our findings might have both physiological and pathological implications.