Muscular activity decline in a Parkinson?s disease animal model

ANA LÍA ALBARRACÍN; FERNANDO DANIEL FARFÁN; PABLO YOSIN TERUYA; ALVARO GABRIEL PIZÁ; FACUNDO LUCIANNA; JORGE HUMBERTO SOLETTA

Villa Carlos Paz, Cordoba

Congreso; XXXIV Reunión Anual SAN 2019; 2019

Sociedad Argentina de Investigación en Neurociencias

Parkinson?s disease diagnosis is currently based on characteristic motor dysfunctions induced by the dopaminergic neurons depletion in the substantia nigra pars compacta (SNpc). The most common Parkinson?s disease animal model induces massive nigrostriatal degeneration by intracerebral infusion of 6-hydroxydopamine (6-OHDA). Using chronic implanted EMG electrodes in a hindlimb muscle of freely moving rats, we evaluate the effect of the PD neurotoxic model in the muscular activity. Power spectrum density (PSD) from each EMG signals obtained from animals with different time post-surgery were analyzed. Our results show that as the time post-lesion increases both frequency parameters decrease. Changes in the PDS have been detected since 3 weeks post-lesion and significant differences were found between different conditions. In addition morphological analysis revealed a transition from a symmetrical to an asymmetrical morphology.