FARFAN Fernando Daniel
congresos y reuniones científicas
Electrophysiological characterization of muscle activation in 6-OHDA rat model of Parkinson?s disease
PABLO YOSIN TERUYA; RAMIRO GUERRERO; ALVARO GABRIEL PIZÁ; ANA LÍA ALBARRACÍN; FERNANDO DANIEL FARFÁN; GABRIEL ALFREDO RUIZ; CARMELO JOSÉ FELICE
Huerta Grande, Cordoba
Congreso; XXIX CONGRESO ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACION EN NEUROCIENCIAS; 2014
Sociedad Argentina de Investigación en Neurociencias
Parkinson´s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons of the substantia nigra which are, in part, responsible for the motor control. PD patients develop motor symptoms (tremor, bradykinesia and rigidity) and, although this symptoms appear early, evidence of the disease progression before the onset of symptoms have not been studied in detail. Electromyographic (EMG) patterns could offer important quantitative information about the motor function declination at different stages of the disease. EMG activity of hindlimb muscles in healthy and PD rats was recorded during dynamic and static contractions (normal gait and specific postures respectively). The PD model was induced by unilateral infusion of the neurotoxin 6-hydroxydopamine (6-OHDA) and the effectiveness of the lesion was verified by the apomorphine test. EMG was characterized in frequency domain by using parametric and non-parametric spectral estimation. Frequency content of dynamic EMG remained into bandwidth of 30-400 Hz (fundamental frequency component at 200 Hz) in healthy rats, while in PD rats the bandwidth was 1-150 Hz (fundamental frequency component at 30 Hz). In static contractions no significant differences were found. Our preliminary results show significant differences between EMG of healthy and parkinsonian rats. Future researches will be aimed to detect patterns of the disease progression from EMG recordings before the appearance of motor symptoms.