Focal adhesion kinase inhibitors in the treatment of solid tumors: Preclinical and clinical evidence

QUISPE, PATRICIA A.; LAVECCHIA, MARTIN J.; LEÓN, IGNACIO E.

DRUG DISCOVERY TODAY

ELSEVIER SCI LTD

Año: 2022 vol. 27

1359-6446

Focal Adhesion Kinase (FAK) is a 125-kDa cytoplasmic protein kinase that is implicated in several cellular functions. This protein is an attractive molecular target for cancer therapy because a wide variety of studies have demonstrated associations between the activation or elevated expression of FAK and tumor progression, invasion, and drug resistance in malignant tumors. Here, we review the strategies used to inhibit FAK activity in solid tumors. We also include an overview of the preclinical (in vitro and in vivo) and clinical studies on FAK inhibitors.