Advances in Quantitative Liquid Chromatography-Mass Spectroscopy for Central Nervous System Melanocortin Hormone Quantification

ONNAINTY, RENÉE; HERRERA, GUADALUPE; GRANERO, GLADYS E.

Chromatographic Methods and Research

Nova Science Publishers

Lugar: Nueva York; Año: 2023; p. 171 - 189

The melanocortin system is related to the regulatory balance of variousphysiological functions including the eating behavior through themelanocortin pathway by stimulating receptors with several endogenousmelanocortin agonists. These agonists include the mature hormone α-melanocyte–stimulating hormone (α-MSH), processed by thehypothalamic pro-opiomelanocortin (POMC) neurons, and are a signalfor decreasing energy intake. Besides, a functional POMC circuit wasalso described in the hippocampus. In addition to its effects in the controlof intake, α-MSH has potent anti-inflammatory and neuroprotectivefunctions. This review outlines key considerations for the analysis of thehormone α-MSH in brain tissue by liquid chromatography tandem massspectrometry (LC-MS/MS) method.