Evaluation of different total Leishmania amazonensis antigens for the development of a first-generation vaccine formulated with a toll-like receptor-3 agonist to prevent cutaneous leishmaniasis

GERMANO MARIA JOSE; LOZANO ESTEBAN; SANCHEZ MARIA VICTORIA; BRUNA FLAVIA; GARCIA-BUSTOS MARIA FERNANDA; SOSA LOCHEDINO, ARIANNA; SALOMON, CRISTINA; FERNANDES, ANA PAULA; MACKERN- OBERTI, JUAN PABLO; CARGNELUTTI DIEGO

MEMóRIAS DO INSTITUTO OSWALDO CRUZ.

FUNDACO OSWALDO CRUZ

Lugar: Rio de Janeiro; Año: 2020

0074-0276

Leishmaniasis is an anthropozoonotic disease causedby intracellular protozoa belonging to the Leishmaniagenus. It is transmitted between animals and humans bythe bite of an infected Phlebotomine female. This diseaseis considered a growing public health problem as aconsequence of the tropicalisation of continents.(1) It isalso considered a neglected disease by the World HealthOrganization, due to the fact that it mainly affects lowincome populations with limited access to health care.Different clinical manifestation can be caused bydifferent species of Leishmania: cutaneous, mucocutaneousand visceral leishmaniasis. However, cutaneousleishmaniasis can be presented as localised, diffuse andatypical.(2) Particularly, L. amazonensis causes localisedcutaneous leishmaniasis.