Synthesis and Anticonvulsant Activity of Amino Acid-Derived Sulfamides

LUCIANA GAVERNET; PASTORE V,; BRUNO-BLANCH LUIS

JOURNAL OF MEDICINAL CHEMISTRY

AMER CHEMICAL SOC

Lugar: Washington; Año: 2009 vol. 52 p. 1592 - 1601

0022-2623

Sulfamide has been proven as promising function for the design of new antiepileptic drugs. A set of amino acid-derived sulfamides has been designed, synthesized and assayed as new anticonvulsant compounds. The experimental data has confirmed the ability of some of the structures to suppress the convulsion originated by the electrical seizure (MES test) at low doses (100 mg/Kg).