Role of Galectine-8 in the outcome of T. cruzi-induced myocarditid

BERTELLI A; LILIANA SANMARCO; PASCUALE CA; AOKI P; POSTAN M; LEGUIZAMON M S

Congreso; REUNIÓN CONJUNTA DE SOCIEDADES DE BIOCIENCIAS; 2017

se adjunta resumenGalectinsarefamilyoflectinsthathaveaffinityforB-galactosides.Galectin-8(Gal-8),whichbelongstothetandemrepeatgroup,possessestwocarbohydraterecognitiondomainsconnectedbyalinkerpeptide.Itiswidelydistributedintissuesandsecretedtotheextracellularmedia,actinginanautocrine/paracrinemanner.Itparticipatesincellularadhesion,migration,andapoptosis,mainlyincancerandautoimmunedisorders.DifferentauthorshavealsoproposedGal-8tobeinvolvedinpro-inflammatoryoranti-inflammatoryevents.TheaimofourworkwastoanalyzetheroleofGal-8inaninflammatorycontextinducedbypathogens.OurmodelisachronicmurineinfectioninducedbyT.cruzi,inC57BL/6J(WT)andGal-8knockout(Gal-8KO)malemice.Previously,wehavereportedthattheinflammationscoreinskeletalandcardiacmuscleofinfectedGal-8KOmicewassignificantlyhighercomparedtoinfectedWTmice,butnodifferencewasfoundinfibrosis.Parasitemiaandsurvivalrateweresimilarbetweengroups.Chagasiccardiomyopathyisachronicdisease,whosedevelopmentisbasedontheinductionofastronginflammationbyTrypanosomacruzipersistenceincardiactissue.Inthisworkwedeepenintheanalysisofthecardiacinflammationdevelopedinourchronicmodel.