Polymorphism in a new ciprofloxacin saccharinate: X-Ray, FTIR and Solid State NMR characterization

ROMAÑUK CB; GARRO LINCK Y; CHATTAH AK; MONTI G; BAGGIO R; GARLAND MT; CUFFINI SL; MANZO RH; OLIVERA ME

San Pedro, Brasil

Simposio; II Simpósio Latino Americano de Polimorfismo e Cristalização em Fármacos e Medicamentos; 2009

A new polymorphic form of Ciprofloxacin saccharinate (CIP-SAC form II) was obtained in a single crystal form. The product wascharacterized, and compared with our previously reported form I. To distinguish both polymorphic forms we used X-ray powderdiffraction, single-crystal X-ray diffraction, Infrared and Solid State NMR (13C-CPMAS). DSC/TGA showed that the reactionbetween precursors is complete and the crystals are obtained with a high degree of purity. Both forms I and II are obtained assalts, as can be observed from the FTIR spectroscopy. Powder X-ray diffraction and 13C CP-MAS allow distinguishing the twopolymorphic forms. Single crystal X-ray diffraction of form II accounted for inter and intra molecular interactions which could beextrapolated to form I.