INVESTIGADORES
OLIVERA Maria Eugenia
congresos y reuniones científicas
Título:
Salt Formation During Cogrinding of Enrofloxacin with Saccharin
Autor/es:
ROMAÑUK CB; MANZO RH; OLIVERA ME
Lugar:
Tandil-Buenos Aires, Argentina
Reunión:
Congreso; Sociedad Argentina de Farmacología Experimental (SAFE). 40a Reunión Anual de SAFE; 2008
Resumen:
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Fluoroquinolone saccharinate
salts (P-060105581) are pharmaceutical alternatives of fluoroquinolones
presenting sweet taste to improve its palatability. The necessity of high
amounts of hot water limits the convenience of the preparation method. The purpose of this work was to investigate
the mechanism of salt formation during cogrinding of solid reactants. Enrofloxacin
saccharinate salt was used as a model compound. Cogrinding in a ball mill of
anhydrous solid reactants was studied. Coground samples were analyzed by FTIR,
XRPD, DSC-TGA at regular intervals from 0-8 hs and compared with enrofloxacin
saccharinate obtained from solution method to establish amount and kind of
interactions. The extent of salt formation during cogrindng was quantified by
DSC and indicates the quick formation of the salt with a faster rate in the
early stages of the process with not less than 45% of the salt formed after 30
min. The reaction was completed after 6
hs. The solid obtained is a polymorph of that obtained from solution. This method yields enrofloxacin saccharinate
in a faster and cheaper way since solvents or boiling are not needed and the
synthesis is completed in a unique step.