INVESTIGADORES
HERRERA CANO Natividad Carolina
artículos
Título:
Aqueous MW eco-friendly protocol for amino group protection
Autor/es:
NARDI MONICA; HERRERA CANO, NATIVIDAD; COSTANZO, PAOLA; OLIVERIO, MANUELA; SINDONA, GIOVANNI; PROCOPIO, ANTONIO
Revista:
RSC Advances
Editorial:
Royal Society of Chemistry
Referencias:
Año: 2015 vol. 5 p. 18751 - 18760
ISSN:
2046-2069
Resumen:
In this paper is presented a new catalyst-free and on-water method for protection of amines and amino acids with di-tert-butyl dicarbonate, 9-fluorenylmethoxycarbonyl chloride, acetyl chloride and tosyl chloride. The protection can be realized in a few minutes under microwave-assistance. The reaction proved to be chemoselective in presence of ambident nucleophiles and water solution of di- tert-butyl carboxylic acid or chloride acid are the only wastes produced.
