Eryptosis is induced by hyperthermia in hereditary spherocytosis red blood cells

RENÉE CRISP*, DAIANA VOTA* (*CONTRIBUCIÓN IDÉNTICA); HUGO DONATO; ELIANA GARCÍA; M. CRISTINA RAPETTI; ROMINA MALTANERI; DANIELA VITTORI; ALCIRA NESSE

CLINICAL CHEMISTRY AND LABORATORY MEDICINE

WALTER DE GRUYTER & CO

Lugar: Berlin; Año: 2016 vol. 54 p. 165 - 168

1434-6621

In pediatric hereditary spherocytosis (HS) patients, anemiafrequently worsens throughout the course of infectiousdiseases, due either to increased hemolysis or to transitoryerythropoietic aplasia [1]. Hemolysis may be so importantthat even asymptomatic individuals can incidentally bediagnosed with HS during a hemolytic crisis secondary tofebrile disease [2]. It has been reported that HS children,especially those under 6 years old, frequently suffer hemolyticcrises triggered by viral infections [2?4]. These reports,along with usual clinical practice, suggest a potentialharmful effect of temperature on erythrocytes which mayaffect their survival.Increasing evidence is now available to demonstratethat erythrocytes can also undergo premature self-destructionthrough a mechanism known as eryptosis, whichshares several features with nucleated-cell apoptosis.Since this process may be accelerated by different environmentalfactors, we decided to study whether hyperthermia?per se? has a direct effect on HS erythrocytes