"Computational study of the SERS response of Ag NPs synthesized by light assisted nanofabrication"

GUERRERO VANEGAS, MARÍA A.; MUÑETÓN ARBOLEDA, DAVID; SANTILLÁN, JESICA MARÍA JOSÉ; SCHINCA, DANIEL CARLOS

Zürich

Encuentro; PHOTONICS ONLINE MEETUP (POM); 2023

ETH Zürich

The physical and chemical properties of metallic nanomaterials are of great interest in the development of applications in various fields of science and technology [1-3]. Particularly, the use of plasmonic nanostructures in Surface-Enhanced Raman Spectroscopy (SERS) is highly promising for applications in analytical chemistry, nanomedicine, and biosensing [4]. Regarding the production of nanostructures, the synthesis of metallic nanoparticles (NPs) by ultrashort pulse laser ablation in solution is an alternative to traditional chemical synthesis methods. While these methods provide good control over structural parameters, they have the disadvantage of leaving chemical residues that can contaminate and hinder certain applications. For this work, we are interested in the synthesis of Ag NPs due to their biocompatibility characteristics and their potential use in biosensors [5-7]. In this study, results of Ag NPs synthesized by femtosecond laser ablation using two different pulseenergies are presented [8]. Their size, composition, and spectral characteristics were determinedthrough UV-VIS spectroscopy, Raman spectroscopy, and TEM microscopy. As the perspective is to use Ag NPs in analyte detection applications with low optical response, the computational study of SERS enhancement is presented. For the numerical calculations, nanoparticle aggregates were simulated with the same distribution shown in the TEM images, and calculations were performed using the Discrete Dipole Approximation (DDA) implemented in the DDSCAT software. References: [1] O.V. Salata, Applications of nanoparticles in biology and medicine, J. Nanobiotechnol. 2 (2004) 1–6. [2] E. Gazit, Self-assembled peptide nanostructures: the design of molecular building blocks and their technological utilization, Chem. Soc. Rev. 36 (2007) 1263–1269. [3] A. Kinkhabwala, Z. Yu, S. Fan, Y. Avlasevich, K. Müllen, W.E. Moerner, Large single molecule fluorescence enhancements produced by a bowtie nanoantenna, Nat. Photonics 3 (2009) 654–657.[4] Pilot R, Signorini R, Durante C, Orian L, Bhamidipati M, Fabris L. A Review on Surface-Enhanced Raman Scattering. Biosensors (Basel). 2019 Apr 17;9(2):57. [5] J.L. Elechiguerra, J.L. Burt, J.R. Morones, A. Camacho-Bragado, X. Gao, H.H. Lara, M.J. Yacaman, Interaction of silver nanoparticles with HIV-1, J. Nanobiotechnol. 3 (2005) 1–10. [6] Y. Mori, T. Ono, Y. Miyahira, V.Q. Nguyen, T. Matsui, M. Ishihara, Antiviral activity of silver nanoparticle/chitosan composites against H1N1 influenza A virus, Nanoscale Res. Lett. 8 (2013) 1–6. [7] D.R. Monteiro, L.F. Gorup, S. Silva, M. Negri, E.R. de Camargo, R. Oliveira, D.B. Barbosa, M. Henriques, Silver colloidal nanoparticles: antifungal effect against adhered cells and biofilms of Candida albicans and Candida glabrata, Biofouling 27 (2011) 711–719.[8] D. Muñetón Arboleda, J.M.J. Santillán, V.B. Arce, M.B. Fernández van Raap, D. Muraca, M.A. Fernández, et al., A simple and “green” technique to synthesize long-term stability colloidal Ag nanoparticles: Fs laser ablation in a biocompatible aqueous medium, Mater. Charact. 140 (2018) 320- 332.