Sex-dependant effects of a yoghurt enriched with proteins in a mouse model of diet-induced obesity

SIROLI, L.; BURNS, P.; BORGO, M.F.; PUNTILLO, M.; DRAGO, S.; FORZANI, L.; D'ALESSANDRO, M.; REINHEIMER J.A.; PEROTTI, M.C.; VINDEROLA, G.

INTERNATIONAL DAIRY JOURNAL

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2021 vol. 114

0958-6946

This research aimed at assessing the effects of a yoghurt enriched with proteins on proinflammatory cytokines and lipids profile using a mouse model of diet-induced obesity in malesand females C57BL/6 mice. The results obtained showed a clear sex-dependent behavior of themice. Female gained less weight gain when compared to male mice independently to the diet. Considering the effect of the diet, when the high fat diet was implemented with yoghurt a reductionof cholesterol and triglycerides, in liver and blood serum of males, and triglycerides in the liver of female mice was observed. For male mice fed with yoghurt, a significant reduction of the levels pro-inflammatory cytokines measured was detected. However, in female mice, the antiinflammatory effect due to yoghurt consumption was observed to a minor extent. The principal component analysis, obtained considering all the data, confirmed that gender or diet was able to group individual animals. A higher variability of data was observed in females compared to malemice, being this probably the reason why less significant differences were observed in the former.