Intracellular signals regulating Na+, K+-ATPase traffic. The protein kinase C pathway

BERTORELLO, A.M.; MENDEZ, C.F.; SZNAJDER, J.I.

Etiology and Treatment of Acute Lung Injury: From Bench to Bedside

IOS Press

Lugar: Amsterdam; Año: 2001; p. 209 - 214

The function of Na+, K+-ATPase in the polarized epithelium of kidney tubules or lung alveolar cells is critical for the vectorial transport of sodium and the consequent isosmotic transport of water. Control of its activity by several hormones and second messengers represents an important mechanism for the cellular adaptation to sudden environmental changes such as high salt diet or pulmonary edema due to congestive heart failure or respiratory distress. Changes in Na+, K+-ATPase activity in response to G protein-coupled receptor signals often occurs by regulating the number of active units within the plasma membrane. Protein kinase C has a critical role in selecting the cargo and/or being responsible for the regulation of cytoskeletal structures responsible for vesicle traffic. Their existence in several isoforms may provide spatial and temporal specificity for Na+, K+-ATPase regulation.