NK cells in Chronic Lymphocytic Leukemia: defective expression of CD62L and IFN production

ZANETTI SAMANTA; MORANDE PABLO; BORGE MERCEDES; NANNINI PAULA; BEZARES FERNANDO; ZWIRNER NORBERTO; GAMBERALE ROMINA; GIORDANO MIRTA

Buenos Aires

Congreso; First French-Argentine Immunology Congress, 2010; 2010

Vol.1No. 3:4doi: 10:3823/413Patients with CLL exhibit a progressive deficiency in the immune response which has been associated to autoimmune disorders, recurrent infections and second malignancies. Given the key role of NK cells in immunesurveillance, we have evaluated the expression of CD62L and CCR7, two molecules involved in NK migration to secondary lymphoid tissues in CD56+CD3- cells from CLL patients and healthy age-matched donors. By flow cytometric analysis we observed a lower proportion of CD62L+ cells in peripheral blood NK cells from CLL patients (30.4 ± 1.6) compared to healthy donors 44.8 ± 2.6 (results are expressed as the mean ± SD, n= 28 and 45 respectively, p