CXCL12-INDUCED CHEMOTAXIS IS IMPAIRED IN T CELLS FROM ZAP-70- CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS

BORGE MERCEDES; NANNINI PAULA; GALLETTI JEREMÍAS; MORANDE PABLO; SÁNCHEZ ÁVALOS JULIO; BEZARES FERNANDO; GIORDANO MIRTA; GAMBERALE ROMINA

Barcelona

Workshop; International Workshop on Chronic Lymphocytic Leukemia; 2009

iwCLL Consortium

T-cells from chronic lymphocytic leukemia (CLL) patients may actually play animportant role in contributing to the onset, sustenance, and exacerbation of the diseaseby providing survival and proliferative signals to the leukemic clone within lymph nodesand bone marrow. By performing chemotaxis assays towards CXCL12 (1μg/ml),CCL21 (1μg/ml) and CCL19 (5μg/ml), we sought to evaluate the migratory potential ofT cells from CLL patients. We found that T cells from CLL patients are less responsiveto these chemokines than T cells from healthy adults (p