INVESTIGADORES
SONEGO Juan Manuel
artículos
Título:
Synthesis and antifungal activity of C-21 steroids with an aromatic D ring
Autor/es:
JUAN M. SONEGO; ADRIANA M. CIRIGLIANO; GABRIELA M. CABRERA; GERARDO BURTON; ADRIANA S. VELEIRO
Revista:
STEROIDS
Editorial:
ELSEVIER SCIENCE INC
Referencias:
Lugar: Amsterdam; Año: 2013 vol. 78 p. 644 - 650
ISSN:
0039-128X
Resumen:
Six analogues of salpichrolides with a simplified side chain (6?11) were synthesized using a new methodology to obtain steroids with an aromatic D-ring. The key step was the elimination of HBr in a vicinal dibromo D-homosteroid by treatment with 1,4-diazabicyclo[2.2.2]octane (DABCO). All new compounds were completely characterized by 2D NMR techniques and tested on two fungal pathogenic species,Fusarium virguliforme and Fusarium solani.
