INVESTIGADORES
BUENO Carlos Alberto
artículos
Título:
Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits
Autor/es:
NIKOLETTA G. NTALLI; FILIPPO COTTIGLIA; CARLOS A. BUENO; LAURA E. ALCHÉ; MARCO LEONTI; SIMONA VARGIU; ERSILIA BIFULCO; URANIA MENKISSOGLU-SPIROUDI; PIERLUIGI CABONI
Revista:
MOLECULES
Editorial:
MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI
Referencias:
Lugar: Basel; Año: 2010 vol. 15 p. 5866 - 5877
ISSN:
1420-3049
Resumen:
The phytochemical investigation of the dichloromethane-soluble part of themethanol extract obtained from the fruits of Melia azedarach afforded one new tirucallanetypetriterpene, 3-tigloylmelianol and three known tirucallanes, melianone, 21-acetoxy-melianone, and methyl kulonate. The structure of the isolated compoundswas mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF massspectrometry. The cytotoxicity of the isolated compounds toward the human lungadenocarcinoma epithelial cell line A549 was determined, while no activity was observedagainst the phytonematode Meloidogyne incognita.
