Protein malnutrition during the critical developmental stage induces type 2 diabetes in adulthood

ECHARTE, STELLA M.; MOTTA, ESTELA; CAMPISANO, SABRINA; LA COLLA, ANABELA; CHISARI, ANDREA N.

Rosario

Congreso; Reunión Anual de la Sociedad Argentina de Fisiología; 2019

Sociedad Argentina de Fisiología

Individuals who suffer malnutrition during gestation, lactation and childhood have an elevated predisposition to develop metabolic diseases in adulthood. The aim was study the effects of protein malnutrition during the stage of development (pregnancy, lactation and childhood) until 120 days of age as an inducer of insulin resistance and obesity in the offsprings.Pregnant rats were fed with a control diet (CD) or a low protein diet (LPD). Female offspring rats received a LPD during gestation, lactation and until they were 120 days of age (MM group), a late LPD that began after 60 days (CM), or a LPD administrated during gestation, lactation and up to 60 days, followed by a CD (MC). The control group received only a CD.The Glucose Tolerance curve showed to have significantly larger areas in MC than MM and MC (p