INVESTIGADORES
DENOFRIO Maria Paula
artículos
Título:
Exploring potooxidative degradation pathways of harmol and harmalol alkaloids in water: effects of pH, excitation sources and atmospheric conditions
Autor/es:
VILLARRUEL, FERNANDO D.; DENOFRIO, M. PAULA; DE LEÓN, TOBÍAS SCHMIDT; ERRA-BALSELLS, ROSA; WOLCAN, EZEQUIEL; GARCÍA EINSCHLAG, FERNANDO S.; CABRERIZO, FRANCO M.
Revista:
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
Editorial:
ROYAL SOC CHEMISTRY
Referencias:
Año: 2024
ISSN:
1463-9076
Resumen:
This work explores the photochemical degradation of cationic species of 7-hydroxy-1-methyl-2H-pyrido[3,4-b]indole or harmol (1C) and the corresponding partially hydrogenated derivative 7-hydroxy-1-methyl-3,4-dihydro-2H-pyrido[3,4-b]indole or harmalol (2C) in aqueous solution. UV-visible absorption and fluorescence emission spectroscopy coupled with multivariate data analysis (MCR-ALS and PARAFAC), HPLC and HRESI-MS techniques were used for both quantitative and qualitative analysis. The formation of hydrogen peroxide reactive oxygen species (ROS) was quantified, and the influence of pH, oxygen partial pressure and photoexcitation source on the photochemical degradation of both compounds was assessed. The potential implications on the biosynthesis of βCs and their biological role in living systems are discussed.
