Photolabile, Immobilizable Caged Compounds: Uncovering a New Species of Ligand Releasing Complexes

BENJAMIN SCHWARTZ; ROLANDO M. CARABALLO; LUIS M. BARALDO

San Diego

Encuentro; 242nd ACS National Meeting; 2012

American Chemical Society

Ruthenium complexes containing 2,2?-bipyridine (bpy) have proven to be very effective in the photoliberation of molecules of biological interest (caged compounds) due to the very well established photolabile nature of some of its compounds (1). For example, the complex [Ru(bpy)2py2]2+ (py=pyridine) has a quantum yield of 0.26 for the photorelease of a pyridine. The ligand 1,10-phenantroline-5,6-dione (phen-dione) is an attractive alternative to the 2,2?-bipyridine, as phen-dione is not only rigid and may share some of 2,2?-bipyridine?s photophysical properties, but phen-dione can also be immobilized on the surface of transition metal oxides, like TiO2 (2). In this presentation we report the synthesis and characterization of the complex [Ru(phen-dione)2py2]2+, including its photophysical properties. Substitution of the pyridine with other molecules can result in a family of caged compounds able to release molecules from various surfaces. (1) ?A New Strategy for Neurochemical Photodelivery: Metal-Ligand Heterolytic Cleavage? Zayat, L.; Calero, C.; Alborés, P.; Baraldo, L. M.; Etchenique R.; J. Am. Chem. Soc., 2003, 125; 882-883. (2) ?Structural effects of self-assembled Prussian blue confined in highly organized mesoporous TiO2 on the electrocatalytic properties towards H2O2 detection?, Gaitán, M.; Gonçales, V. R.; SolerIllia, G. J. A. A.; Baraldo, L. M.; Córdoba de Torresi, S. I.; Biosens. & Bioelect. 2010, 26, 890-893.