CYCLODEXTRINS-METAL HALIDE COMPLEXES AS A USEFUL REACTANT IN STEREOSELECTIVE a-HALOGENATION OF KETONES

KRAPACHER, CLAUDIO R.; VELASCO, MANUEL I.; ROSSI, LAURA I.

Congreso; 4th International IUPAC Conference on Green Chemistry; 2012

Several metallic salts have showed to be very efficient reactants or catalyst in organic reactions, but their poor stability under atmospheric conditions is a disadvantage for its use. An alternative to improve the physicochemical properties of these salts without loosing their activity is the formation of complexes with cyclodextrins (CD)1. Cyclodextrins are cyclic oligomers of glucose with 6, 7 or 8 glucose units for α, β and γ cyclodextrin respectively. In addition to the improvement in stability, the chiral properties of cyclodextrin make these complexes suitable for asymmetric synthesis. It’s well known that pharmaceutical industries are one of the less Green, so the development of synthetic procedures that fulfill the green chemistry principles in the area is desirable. Due to it broad use as synthon we propose the use of a CD- metal halide complexes for stereoselective synthesis of α-haloketones.