INVESTIGADORES
GLISONI Romina Julieta
congresos y reuniones científicas
Título:
Encapsulation of Curcumin in Pristine and Glucosylated Poly(ethylene oxide)-b-poly (propylene oxide) Polymeric Micelles Improves the Antitumoral Efficacy In Vitro and the Uptake In Vivo
Autor/es:
LECOT N.; GLISONI R.J.; ODDONE N.; FERNANDEZ M.; GAMBINI J.P. ; CABRAL P.; SOSNIK A.
Lugar:
CancĂșn, MĂ©xico
Reunión:
Congreso; International Material Research Congress (IMRC); 2015
Institución organizadora:
Materials Research Society
Resumen:
Curcumin (CUR), a polyphenolic anti-inflammatory, antioxidant, anti-proliferative and antiangiogenic compound derived from Curcuma longa has gained interest in the therapy of different disease, including cancer (1). However, its poor aqueous solubility challenges the oral and parenteral administration (2). The goal of this work was to explore the encapsulation of CUR into polymeric micelles (PMs) of made of pristine poly(ethylene oxide)-b-poly(propylene oxide) block copolymers (PEO-PPO) and their glucosylated derivatives and evaluate their antitumoral activity in vitro employing a murine mammary cell line (3).