INVESTIGADORES
PELLEGRINET Silvina Carla
artículos
Título:
First Total Synthesis of (+)-Neplanocin B
Autor/es:
MARÍA J. COMÍN; SILVINA C. PELLEGRINET; JUAN B. RODRÍGUEZ
Revista:
Arkivoc
Editorial:
Arkat USA
Referencias:
Año: 2005 vol. XII p. 205 - 213
ISSN:
1424-6376
Resumen:
(+)-Neplanocin B, the unnatural isomer of a minor component of the neplanocin family of antibiotics was enantioselectively synthesized starting from D-ribono-1,4-lactone. This synthetic strategy employed (+)-9-[(1R, 2R, 5S)-5-Benzyloxy-3-(benzyloxy)methyl-2-hydroxy-cyclopent-3-en-1-yl]-6-chloropurine as an advanced synthetic intermediate.
