A DFT study on the Regioselectivity of the Reaction of Dichloropropynylborane with Isoprene

MARÍA A. SILVA; SILVINA C. PELLEGRINET; JONATHAN M. GOODMAN

JOURNAL OF ORGANIC CHEMISTRY

American Chemical Society

Lugar: Washington; D. C.; Año: 2003 vol. 68 p. 4059 - 4066

0022-3263

This theoretical study deals with the reaction of isoprene and dichloropropynylborane. We report the results of the DFT calculations applied to the two processes involved, Diels-Alder cycloaddition and 1,4-alkynylboration. The boron influences both the chemoselectivity and the regioselectivity of this reaction through secondary orbital interactions (SOI hereafter) that give rise to transition structures with strong [4 atom + 3 atom] character. The “meta” regioselectivity observed experimentally for the reaction between 2-substituted 1,3-dienes and alkynyldihaloboranes has been explained as the result of the higher stabilization of these transition structures with “meta” orientation. Intrinsic Reaction Coordinate calculations were performed to determine connectivities, and established the remarkable result that the geometrically very similar transition structures leading to both regioisomeric 1,4-alkynylboration products correspond to different pathways. For the “meta” orientation a direct alkynylboration of the diene through a concerted transition structure was found.