Crystalline structures of l-cysteine and l-cystine: a combined theoretical and experimental characterization

SU, YANGYANG; HESSOU, ETIENNE P.; COLOMBO, ESTEFANIA; BELLETTI, GUSTAVO; MOUSSADIK, ALI; LUCAS, IVAN T.; FROCHOT, VINCENT; DAUDON, MICHEL; ROUZIÈRE, STÉPHAN; BAZIN, DOMINIQUE; LI, KEZHI; QUAINO, PAOLA; TIELENS, FREDERIK

AMINO ACIDS

SPRINGER

Lugar: Berlin; Año: 2022

0939-4451

It is assumed that genetic diseases affecting the metabolism of cysteine and the kidney function lead to two different kinds of pathologies, namely cystinuria and cystinosis whereby generate l-cystine crystals. Recently, the presence of l-cysteine crystal has been underlined in the case of cystinosis. Interestingly, it can be strikingly seen that cystine ([-S-CH2-CH-(NH2)-COOH]2) consists of two cysteine (C3H7NO2S) molecules connected by a disulfide (S?S) bond. Therefore, the study of cystine and cysteine is important for providing a better understanding of cystinuria and cystinosis. In this paper, we elucidate the discrepancy between l-cystine and l-cysteine by investigating the theoretical and experimental infrared spectra (IR), X-ray diffraction (XRD) as well as Raman spectra aiming to obtain a better characterization of abnormal deposits related to these two genetic pathologies.