Altered expression of Transforming Growth Factor Beta isoforms in bovine cystic ovarian disease.

VALENTINA MATILLER; MATÍAS L. STANGAFERRO; PABLO U. DÍAZ; HUGO H. ORTEGA; FLORENCIA REY; EMILIA HUBER; NATALIA R. SALVETTI

REPRODUCTION IN DOMESTIC ANIMALS (1990)

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2014 vol. 49 p. 813 - 823

0936-6768

Cystic ovarian disease (COD) is one of the main causes of infertility in dairy cattle. It has been shown that intra-ovarian factors may contribute to follicular persistence. Transforming growth factor beta (TGFB) isoforms are important paracrine and autocrine signaling molecules that regulate ovarian follicle growth and physiology. Considering the importance of these factors in the ovarian physiology, in the present study, we examined the expression of TGFB isoforms (TGFB1, TGFB2 and TGFB3) in the ovary of healthy cows and animals with spontaneous and ACTH-induced COD. In the estrus-synchronized control group, the expression of TGFB1 in granulosa and theca cells was higher in spontaneous cysts than in atretic or tertiary follicles (p