INVESTIGADORES
SANCHEZ SANCHEZ Maria Victoria
artículos
Título:
Improved Immune Response to Recombinant Influenza Nucleoprotein Formulated with ISCOMATRIX
Autor/es:
CARGNELUTTI, DIEGO ESTEBAN; SANCHEZ, MARIA VICTORIA; ALVAREZ, PAULA; BOADO, LORENA; GLIKMANN, GRACIELA; MATTION, NORA; SCODELLER, EDUARDO
Revista:
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
Editorial:
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
Referencias:
Lugar: Seul; Año: 2012 vol. 22 p. 416 - 421
ISSN:
1017-7825
Resumen:
Current influenza vaccines elicit antibodies effective against
homologous strains, but new strategies are urgently needed
for protection against emerging epidemic or pandemic
strains. Although influenza vaccine candidates based on
the viral nucleoprotein (NP) or matrix protein do not elicit
sterilizing immunity, they have the advantage of inducing
immunity that may cover a larger number of viral strains.
In this study, recombinant NP produced in Escherichia
coli was purified and formulated in combination with the
adjuvant ISCOMATRIX. This formulation increased a
NP-specific immunity in mice, with a Th1 profile, and
may constitute a promising low-cost influenza vaccine
candidate, with ability to stimulate humoral and cellular
immune responses.