Hemosiderin, a possible biomarker for sudep?

ANDRESSA SAMPAIO PEREIRA; PATRÍCIA DE MORAIS FERREIRA BRANDÃO; JERÓNIMO A. AUZMENDI; ALBERTO LAZAROWSKI

REVISTA NEUROCIENCIAS

Unifesp

Año: 2021

0104-3579

Epilepsy is one of the neurological diseases of complex etiology that affects around 50 millionpeople worldwide and is characterized by abnormal electrical activity and recurrent seizures.Uncontrolled generalized repetitive tonic-clonic seizures (GTCS) are the main causes ofunexpected sudden death in epilepsy (SUDEP). Hypoxic stress induced by seizure results inneurocardiogenic dysfunctions, including iron overload and cardiomyopathy (IOC) which isrelated to severe lipid peroxidation caused by the production of reactive oxygen species (ROS).ROS induces recurrent seizure activity, favoring the overexpression of P glycoprotein (P-gp) inthe heart. P-gp plays a depolarizing role in cardiomyocyte membranes and potassium (Kir)channels control cellular excitability regarding the repolarization of the cardiac action potential.All these events result in a possible appearance of severe bradycardia and fatal arrhythmia.Several studies have sought evidence for different possible biomarkers for potential predictionof the risk of SUDEP avoiding its fatal outcome.