Analysis of the genetic diversity and phylogenetic relationships of putative human papillomavirus types

DIEGO CHOUHY; ELISA BOLATTI; GERMÁN R. PÉREZ; ADRIANA A. GIRI

JOURNAL OF GENERAL VIROLOGY

SOC GENERAL MICROBIOLOGY

Lugar: London; Año: 2013 vol. 94 p. 2480 - 2488

0022-1317

More than 170 human papillomavirus (HPV) types have been completely sequenced, curated and divided into five genera:Alphapapillomavirus, Betapapillomavirus, Gammapapillomavirus, MupapillomavirusandNupapillomavirus. With the application of PCR methods, hundreds of putative novel HPV types have been identified as PCR amplicons in mucosa and skin. However, at present there are no studies reporting a systematic search of the currently known L1 amplicons and their phylogenetic relationships. This survey revealed the existence of at least 202 different putative HPV types that are pending for full-genome characterization: five alphapapillomaviruses, 37 betapapillomaviruses, 159 gammapapillomaviruses and one mupapillomavirus. All potential viruses of the generaAlphapapillomavirusandBetapapillomaviruswere grouped in the defined species, while 59 putative gammapapillomaviruses types were segregated in 21 unidentified putative species. These data highlight the need for progress in the identification of additional taxa of the familyPapillomaviridaein order to elucidate the diversity, evolution and medical implications of these viruses.