BLOCK OF CCL2 SECRETION INHIBITS PRO-INFLAMMATORY MACROPHAGE ACTIVATION IMPROVING AXONAL REGENERATION AFTER SEVERE SPINAL CORD INJURY

SCHMIDT, JULIETA; UCEDA, ANA; SGARIGLIA, ALEJANDRA; H.R QUINTÁ

Congreso; Sociedad Argentina de Investigación Clínica; 2023

Spinal cord injury (SCI) is a traumatic pathology that results in temporary or permanent damages in the spinal circuits, which disrupts the flow of information between brain and SC. The aim of this study is to focus on targeting the dynamic relationship between mechanical injury and inflammation response in order to improve the axonal regeneration and motor recovery.The size of the spinal lesion caused by the mechanical injury increases it after the secondary damage caused by the inflammatory response. This process is triggered by recruitment of pro-inflammatory macrophages to the injury site. The molecule that initiates this pathway is the Chemokine C-C Ligand2 (CCL2), secreted by reactive astrocytes to binds macrophage. Since our group has an extensively experience in the use of Netrin-1 (N1) as a therapeutically approach to promotes axonal regeneration, we detected that N1 treatment, furthermore, inhibited significantly the increased lesion size after secondary damage (p