Effects of maternal dietary olive oil on pathways involved in diabetic embryopathy

HIGA ROMINA; ROBERTI SABRINA; MUSIKANT DANIEL; MARÍA BELÉN MAZZUCCO; WHITE VERÓNICA; JAWERBAUM ALICIA

REPRODUCTIVE TOXICOLOGY (ELMSFORD, N.Y.)

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2014 vol. 22 p. 185 - 195

0890-6238

Maternal diabetes induces a pro-oxidant/pro-inflammatory intrauterine environment related to the induction of congenital anomalies. Peroxisome proliferator activated receptors (PPARs) are transcription factors that regulate antioxidant and anti-inflammatory pathways. We investigated whether maternal diets supplemented with olive oil, enriched in oleic acid, a PPAR agonist, can regulate the expression of PPAR system genes, levels of lipoperoxidation and activity of matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs)in embryos and decidua from diabetic rats. The embryos and decidua from diabetic rats showed reduced expressionof PPARs and increased concentrationoflipoperoxidation,MMPs and TIMPs, whereas the maternaltreatments enriched in olive oil increased PPAR in embryos and PPAR and PPAR-coactivator-1 expression in decidua, and increased TIMPs concentrations and decreased lipoperoxidation and MMPs activity in both tissues. Thus, maternal diets enriched in olive oil can regulate embryonic and decidual PPAR system genes expression and reduce the pro-oxidant/pro-inflammatory environment during rat early organogenesis. ©