Dosimetry Optimization System and Integrated Software (DOSIS): a comparison against FLUKA code results over a standard phantom

PEDRO PEREZ; FRANCESCA BOTTA; MARTA CREMONESI; MAHILA FERRARI; FRANCESCO GUERRIERO; FRANCISCO MALANO; GUIDO PEDROLI; MAURO VALENTE

Montevideo

Congreso; 10th Latin American Symposium on Nuclear Physics and Applications; 2013

CLAF Universidad de la Republica

Actually, dual-imaging facilities allow obtainance of both mass and activity patient-specific dis-tributions perfectly correlated, which are important to improve dose distributions estimations andradioimmunotherapy treatment planifications accuracy.Calculus methods at voxel level require both quantitative and qualitative validation to obtain im-provements in patient-specific dosimetry. The present work presents advances on the developmentof a novel computational tool dedicated to 3D patient-specific dosimetry at voxel level; and itsresults analysis and visualization. With the aim of providing a dosimetric tool for planar andtridimensional methods at voxel level, as well as the development of a platform based on full-stochastic methods for α-, β - and γ-emitters used in radiopharmaceutical applications. DOSISis based on the Boltzmann radiation transport equation to realize energy delivering calculations.Procedures for 2D and 3D dosimetry have been designed tacking into accont established formal-ism and standards on MIRD Pamphlets. Anatomic and metabolic images, and dose maps resultingof this calculus are analysed and procesed by a special developed and designed software.DOSIS has been preliminary validated on some standard clinic cases in comparison whith otherstandard procedures used commonly in radionuclide treatments, showing great accordance onits results and a friendly user usability. Finally, a dose calculation over a standard phantom isperformed using DOSIS calculation code and FLUKA, validating the radiation transport code ofDOSIS.