Grape pomace supplementation attenuates metabolic parameters in subjects with overweight and obesity.

ASUS, N; PERDICARO DJ; MUSCIA V; RODRIGUEZ LANZI C; ANTONIOLLI, A; VAZQUEZ PRIETO MA

Congreso Virtual organizado por la Sociedad Europea de Metabolismo y Nutrición Clínica

Congreso; The European Society for Clinical Nutrition and Metabolism (ESPEN); 2021

European Society of Clinical Nutrition and Metabolism

Rationale: Grape pomace (GP) is a waste product obtained after the winemaking process, which contains relatively high amounts of bioactive compounds like polyphenols and dietary fiber. We previously showed that Malbec GP supplementation improves metabolic parameters in rats with metabolic syndrome. The aim of this study was to evaluate weather GP supplementation could improve lipid profile and others metabolic parameters in overweight and obese subjects. Methods: Subjects with body mass index (BMI) ≥ 27 were assigned to consume a granola enriched with 10 g of GP (containing 5.3 g of dietary fiber and 400 mg of phenolic compounds), for 6 weeks. Anthropometric and metabolicvariables were determined at the beginning and at the end of the experimental period. Data were analyzed using the statistical GraphPad Prism version 5.00. Statistical significances were assessed by paired Student?s t test.Results: 10 subjects, age 38.8 ± 12.3 years, were included. Anthropometric and metabolic variables are shown in Table 1. Supplementation with 10 g of malbec GP-enriched granola significantly reduced waist circumference, systolic bloodpressure, total cholesterol and LDL cholesterol levels. No significant differences were observed in body weight, BMI, HDL cholesterol, triglycerides, glycemia, insulinemia and CRP levels.Conclusion: GP supplementation had a positive impact on the lipid profile since it significantly decreased total cholesterol and LDL cholesterol. Overall, consumption of GP, a winemaking residue rich in bioactive compounds, can be a beneficial, sustainable and low-cost strategy to be use in the food industry as a functional food to counteract the adverse effects associated with overweight and obesity.