Argentine garlic cultivars characterization by their health-benefits

VAZQUEZ MA; RENNA NF, CACCIAMANI V; GONZALEZ ES, LAMA MC, GALMARINI CR, MIATELLO RM.

Holanda

Simposio; 5th International ISHS Symposium on Edible Alliaceae (ISEA) 2nd World; 2007

International Society for horticultural science

Argentine garlic cultivars characterization by their health-benefits Vazquez MA; Renna NF, Cacciamani V; Gonzalez ES, Lama MC, Galmarini CR* and Miatello RM. School of Medicine, National University of Cuyo and IMBECU-CONICET. *EEA INTA La Consulta, Mendoza, Argentina. Dietary factors play a key role in the development of several human diseases, including metabolic syndrome and cardiovascular disease. Over the centuries, garlic (Allium sativum) has been considered as a functional food with prophylactic and therapeutic effects. The objective was to characterize Argentine garlic cultivars through their health benefits on a metabolic syndrome experimental model in rats. Administration of 10% fructose solution as drinking water was used to achieve the pathological model (FFR). Aqueous garlic extract from Fuego INTA (F) and Morado INTA (M) cultivars were administrated by gavage (150 mg/kg/d) to FFR and control groups. The experimental design included 6 groups (n=8 each) treated during 8 weeks. Variables associated to metabolic syndrome: systolic blood pressure (mmHg), basal glycemia (mg/dL) and lipid profile (mg/dL) were examined. In addition, oxidative stress status was evaluated through aortic NAD(P)H oxidase activity (counts/min/mg) and plasma TBARS concentration (umol/L). Data were processed by ANOVA and Newman-Keuls post-test. Table shows the results as mean±sem. * indicates p<0,01 v C, and º p<0,01 v FFR Variables Control C+F C+M FFR FFR+F FFR+M SBP 119±1,3 120±0,5 121±0,8 135±1,5* 126±1,8º 125±1,1º Glycemia 135±5 132±11 133±7 186±8* 142±10º 153±8º Triglycerides 68±10 39±6 39±3 109±13* 78±14 86±9 NADPHoxid. 62±9 65±13 65±10 108±13* 50±7º 78±10º TBARS 2,18±0,06 2,21±0,05 2,12±0,07 2,63±0,1* 2,17±0,04º 2,42±0,09º Changes in FFR group attributable to the pathological model development were reverted by garlic extract administration. The beneficial effect was slightly higher when F was administrated. Data suggest a useful role of natural antioxidants in the prevention of some of the cardiovascular and metabolic alterations and oxidative stress associated to this pathology.