Renal modifications induced by fructose overload in rats: prevention by dietary (-)-epicatechin administration

PRINCE PD; VAZQUEZ PRIETO MA; GEREZ EM; FRAGA CG; GALLEANO M

Londres

Encuentro; The 16th biennial meeting for the Society for Free Radical Research International (SFRRI); 2012

Metabolic syndrome is a risk factor for kidney disease. This study evaluated the effects of (-)-epicatechin (EC) supplementation on oxidative alterations and inflammation in the kidney of rats subjected to a model of metabolic syndrome. Male Sprague-Dawley rats were divided into three groups: control group (C) receiving control diet and tap water; fructose group (F)  receiving control diet and 10% (w/v)  fructose in the drinking water and fructose + (-)-epicatechin group (F+EC) receiving fructose and the diet supplemented with EC (20 mg/kg BW/d). Fructose overload caused a significant increase in thiobarbituric acid reactive substances (TBARS) in renal cortex, which was prevented by EC (C=0.98±0.07; F=1.27±0.10* and F+EC=0.91±0.07 mmol MDA/mg protein; *p