VARIABILITY OF PDYN AND OPRK1 GENES IN FOUR ARGENTINIAN POPULATIONS AND ITS GENETIC ASSOCIATION WITH CLINICAL VARIABLES RELATED TO ACUTE POSTSURGICAL PAIN

DI SANTO MEZTLER G.P.; SCHIAFFI J.; RIGALLI A.; ESTEBAN TORNÉ M.E.; MARTINA P.F. ; CATANESI C.I.

Journal of Basic and Applied Genetics

Sociedad Argentina de Genetica

Lugar: CABA; Año: 2022

Several population studies showed an association between variation in pain sensitivity and geneticpolymorphisms located in Prodynorphin (PDYN) and Kappa Opioid Receptor (OPRK1) human genes.We analysed polymorphisms of these two genes to characterise their variation in Argentinianpopulations, as well as to evaluate their association with acute pain sensitivity. We studied 11genetic markers in individuals from four locations in Argentina (Ciudad Autónoma de BuenosAires, La Plata, Resistencia, and Misión Nueva Pompeya), calculated the population parameters,and evaluated the possible association among pain sensitivity, clinical, and genetic variablesthrough a Generalised Estimating Equation model. High linkage disequilibrium was observed inthe four populations for both genes, and significant differences were found among frequencies ofArgentinian populations and those from other continents reported in the 1000 Genomes Project.Four PDYN gene polymorphisms from 3´ untranslated region and exon 4 showed associationwith acute pain sensitivity. One genotype of each of these polymorphisms was associated with ahigher pain sensitivity, probably related with the activation of the N-methyl-D-aspartate (NMDA)receptors. We found a strong association with acute pain for the following clinical variables: 1)time after surgery, 2) intravenous klosidol supplied every 8 h, and 3) type of incision. Our resultshighlight the importance of a regional study of genetic variants which influence pain sensitivityand analgesic response.