Chemoenzymatic synthesis of novel N-(2-Hydroxyethyl)-b-peptoid oligomer Derivatives and application to porous polycaprolactone films

LEANDRO MONSALVE; PETROSELLI GABRIELA; ERRA BALSELLS ROSA; VAZQUEZ ANALIA; BALDESSARI ALICIA

POLYMER INTERNATIONAL

JOHN WILEY & SONS LTD

Lugar: LOndres; Año: 2014 vol. 63 p. 1523 - 1530

0959-8103

Poly[N-(2-hydroxyethyl)-b-propylamide] oligomer is synthesized using a simple enzymatic procedure involving Candida antarctica lipase B. This novel compound is obtained by a green and chemoselective method from economic reactants in good yield. The b-peptoid oligomer is characterized by spectroscopic methods showing low molecular weight and low dispersity. Two derivatives of the b-peptoid oligomer are prepared by acetylation and by grafting polycaprolactone by ring opening polymerization from the pendant hydroxyl groups. These products are blended with polycaprolactone to make films by solvent casting. The inclusion of the acyl derivatives of the b-peptoid to polycaprolactone affects the morphology of the film yielding microstructured and nanostructured patterns.