INVESTIGADORES
LO NOSTRO Fabiana Laura
artículos
Título:
Effects of waterborne exposure to 17B estradiol and 4-tert-octylphenol on early life stages of the South American cichlid fish Cichlasoma dimerus
Autor/es:
MEIJIDE, F.; REY VAZQUEZ, G.; PIAZZA, Y.; BABAY, P.; ITRIA, R.; LO NOSTRO, F.
Revista:
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Editorial:
ACADEMIC PRESS INC ELSEVIER SCIENCE
Referencias:
Lugar: Amsterdam; Año: 2016 vol. 124 p. 82 - 90
ISSN:
0147-6513
Resumen:
Estrogenicchemicalsareoftendetectedintheaquaticenvironmentandcannegativelyaffectanimaldevelopment andreproduction.Inteleost fishes, thehormonalregulationduringacriticalperiodoflarvaldevelopmenthasastronginfluence ongonadalsexdifferentiation;thusthisprocessmaybeaf-fected bytheexposuretoenvironmentalestrogens.Inthisstudy,we first assessedthelethalacutetoxicityofthenaturalestrogen17β-estradiol(E2) andtheweakerestrogenmimics4-tert-octylphenol(OP) and4-nonylphenol(NP)onlarvalstagesoftheSouthAmericancichlid fish Cichlasomadimerus. Inafurther experiment,weanalyzedtheeffectsofchronicwaterborneexposuretoE2 and OPongonaddevelopment andsexdifferentiation.ExposuretohighconcentrationsofE2 had apronouncedfeminizingeffect directingsexdifferentiationtowardsovariandevelopment,whiletestisdevelopmentwasinhibitedat alower,environmentallyrelevantconcentration.AmongOP-exposed fish, 15?38.5% ofthemalesex-hibited testicularoocytes(TOs),acommonlyreportedbiomarkerofestrogenicexposure.However,sinceTOs werealsorecordedincontrolmalesandtheproportionofmaleswithTOswasnotsignificantlyhigher inOPtreatments,theiroccurrencecouldnotbeattributedtoOPexposure.Inaddition,TOsdidnotseem toimpairmalegonaddevelopmentandfunctionalitysincenormalspermatogenesiswasobservedin testesofOP-treated fish. TheseresultsindicatethatE2 occurring intheSouthAmericanaquaticen-vironment mayaffectmalereproductivedevelopmentandposeariskforwild C. dimerus, especiallyunder prolongedexposure,whiletheeffectsofweakerxenoestrogenssuchasOPwouldbenegligibleforgonad developmentinthisspecies.Asillustratedbythisstudy,thenaturaloccurrenceofTOsindicatesthat conclusionsconcerningthecausesofthisphenomenonmustbedrawnwithcare.
