INVESTIGADORES
COCERES Veronica Mabel
artículos
Título:
In vitro evaluation of â-carbolines alkaloids as potential anti-Toxoplasma agents
Autor/es:
MARIA L. ALOMAR; FEDERICO A. O.; AGUSTINA GANUZA; VERONICA M. COCERES; FRANCO M. CABRERIZO; SERGIO O. ANGEL
Revista:
BMC Research Notes
Editorial:
BioMed Central Editorial
Referencias:
Año: 2013
ISSN:
1756-0500
Resumen:
Toxoplasmosis is a worldwide infection produced by the protozoan parasite Toxoplasma gondii, which causes chorioretinitis and neurological defects in congenitally infected newborns or immunodeficient patients. The efficacy of the current therapy is limited, primarily by serious host toxicity and/or the development of drug-resistant parasites. During the last years, research has been focused on the development of new drugs against T. gondii. â-Carbolines (âCs), such as harmane, norharmane and harmine, are a group of naturally occurring alkaloids that show microbicidal activity. In this work, harmane, norharmane and harmine were tested against T. gondii.
