ROLE OF cGAS-STING AXIS IN IMMUNE RESPONSE AGAINST RESPIRATORY BRUCELLA ABORTUS INFECTION

PAIVA ALONSO IVAN; RAIANY ARAÚJO SANTOS; SERGIO COSTA OLIVEIRA; FERRERO MARIANA CRISTINA; BALDI PABLO C

Congreso; LXIX Reunión de la Sociedad Argentina de Inmunología; 2021

The cGAS-STING axis is activated upon microbial DNA recognition in the cytosol to initiate an innate immune response, including proinflammatory cytokines and type I interferons. We evaluated the role of these receptors in the response to respiratory infection by Brucella abortus.In vitro infections on samples from knock-out (KO) and wild type (WT) mice revealed that STING, but not cGAS, restricts intracellular growth of B. abortus in murine lung explants (LE) and alveolar macrophages (AM) at 24h (p