DIVERGENT STRAINS OF HUMAN T-LYMPHOTROPIC VIRUS TYPE 1 (HTLV-1) WITHIN COSMOPOLITAN SUBTYPE IN ARGENTINA

MARIA EMILIA EIRIN; DARIO DILERNIA; CAROLINA BERINI; LEANDRO JONES; MARIA A PANDO; MIRNA BIGLIONE

AIDS RESEARCH AND HUMAN RETROVIRUSES

MARY ANN LIEBERT INC

Lugar: New Rochelle, Nueva York; Año: 2008 vol. 24 p. 1237 - 1244

0889-2229

HTLV-1 Cosmopolitan subtype Transcontinental subgroup A has been described among aboriginal communities from the northwest endemic area of Argentina. Moreover, Transcontinental subgroup A and the Japanese subgroup B were reported among blood donors from the nonendemic central region of the country. We carried out the first HTLV-1 phylogenetic study in individuals residing in Buenos Aires capital city. Phylogenetic analysis performed on the LTR region showed that all 44 new strains clustered within the Cosmopolitan subtype, with 42 (95.4%) belonging to Transcontinental subgroup A. Of them, 20 (45.5%) strains grouped in the large Latin American cluster and 4 (9.1%) in the small Latin American cluster. The majority of them belonged to individuals of nonblack origin, grouped with Amerindian strains. Three (6.8%) were closely related to South African references and two monophyletic clusters including only HIV/HTLV-1 coinfected individuals were observed. Interestingly, two (4.5%) new sequences (divergent strains) branched off from all five known Cosmopolitan subgroups in a well-supported clade. In summary, these findings show that HTLV-1 Cosmopolitan subtype Transcontinental subgroup A is infecting residents of Buenos Aires, a nonendemic area of Argentina, and confirm the introduction of divergent strains in the country.