Diagnostic performance of commercial IgM and IgG enzyme-linked immunoassays (ELISAs) for diagnosis of Zika virus infection

KIKUTI, MARIANA; TAURO, LAURA B.; MOREIRA, PATRÍCIA S. S.; CAMPOS, GÚBIO S.; PAPLOSKI, IGOR A. D.; WEAVER, SCOTT C.; REIS, MITERMAYER G.; KITRON, URIEL; RIBEIRO, GUILHERME S.

VIROLOGY JOURNAL

BIOMED CENTRAL LTD

Lugar: Londres; Año: 2018 vol. 15

1743-422X

In a setting of endemic dengue transmission, the ZIKV IgM-ELISA had high specificity, but poorsensitivity. In contrast, the ZIKV IgG-ELISA showed low specificity, particularly for patients previously exposed todengue infections. This suggests that this ZIKV IgM-ELISA is not useful in confirming a diagnosis of ZIKV infection in suspected patients, whereas the IgG-ELISA is more suitable for ZIKV diagnosis among travelers, who reside in areasfree of flavivirus transmission, rather than for serosurveys in dengue-endemic areas.