Circulating IGF-1 and its role in cancer: lessons from the IGF-1 gene deletion (LID) mouse.

YAKAR, S; PENNISI, P; ZHAO, H; ZHANG, Y; LEROITH, D

Novartis Foundation Symposium

Año: 2004 vol. 2004 p. 3 - 9

Recent epidemiological studies have suggested a statistical connection between serum IGF-1 levels in the upper quartile of the normal range and the relative risk of developing certain cancers. Our studies have focused on mouse models where circulating IGF-1 levels are reduced, while tissue expression of IGF-1 is normal. These mice show a lower risk for the development of colon and breast cancers and metastases when compared with control mice, and lend support to the hypothesis that circulating IGF-1 may be linked to cancer cell growth.