Effects of antibiotics in the kinetics of colonization of Lactobacillus fermentum and Streptococcus pneumoniae in the respiratory tract of mice

CANGEMI DE GUTIERREZ, ROSA; VIVIANA SANTOS,; MARTA CECILIA,; MARIA ELENA FATIMA NADER

Annals Of Clinical Microbiology And Antimicrobials

Medwell online

Lugar: Londres; Año: 2004 vol. 3 p. 23 - 32

Abstract. Ampicillin was selected to further study the effect of this antibiotic on the colonization capability of S. pneumoniae and L. fermentum intranasally inoculated in a mice experimental model. The sensitivity of S. pneumoniae and L. fermentum to antibiotics was evaluated by different ?in vitro? techniques. The results showed that both microorganisms have a typical pattern of sensitivity to antibiotics in these assays. The ?in vivo? experiments showed that the treatment with Ampicillin increased the number of lactobacilli and neumococci in the groups of mice treated only with one of the microorganisms. In those mice treated with Lactobacillus, challenged later with neumococci and treated with Ampicillin, the pathogen in lung decreased on the 4th day, disappearing completely after on. The histological studies showed that the antibiotic treatment decreased the inflammatory response produced by the pathogen at the lung and trachea levels.