Systemic oxidative stress in old rats is associated with both osteoporosis and cognitive impairment

TORRES ML; WANIONOK NE; MC CARTHY AD; MOREL GR; FERNANDEZ JM

EXPERIMENTAL GERONTOLOGY

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2021

0531-5565

Aging is associated both with an increase in memory loss and withcomorbidities such as Osteoporosis, which could be causatively linked. In thepresent study, a deleterious effect on bone is demonstrated for the first time in amodel of aged rats with impaired memory. We show that bone marrowprogenitor cells obtained from rats with memory deficit have a decrease in theirosteogenic capacity, and an increase both in their osteoclastogenic profile andadipogenic capacity, when compared to aged rats with preserved memory. Ratswith impaired (versus preserved) memory also show alterations in long-bonemicro-architecture (decreased trabecular bone and osteocyte density, increasedTRAP-positive osteoclasts), lower bone quality (decreased trabecular bonemineral content and density) and an increase in bone marrow adiposity.Interestingly, the development of bone alterations and memory deficit in old ratsis associated with significantly higher levels of serum oxidative stress (versusunaffected aged rats). In conclusion, from a multi-scale study we have found forthe first time a relationship between alterations in bone quality and memoryimpairment in an aged rat model.