Editorial: Glyphosate Herbicide as Endocrine Disruptor and Probable Human Carcinogen: Current Knowledge and Future Direction

LORENZ, VIRGINIA; ROSSETTI, MARÍA FLORENCIA; DALLEGRAVE, ELIANE; MILESI, MARÍA MERCEDES; VARAYOUD, JORGELINA

Frontiers in Endocrinology

Frontiers Media S.A.

Lugar: Lausanne; Año: 2021 vol. 12 p. 772911 - 772911

Glyphosate-based herbicides (GBHs) are the pesticidesmost globally used and the rate of usage does not appear to slow. Although farmers, applicators and their families are the most susceptible population, some biomonitoring studies are indicating that glyphosate and aminomethylphosphonic acid (AMPA), its main metabolite, are found in biological fluids in populations from non-agricultural contexts (1, 2). This is a real concern because the extent of the population potentially exposed to glyphosate herbicide is greater than we think and the consequences become more difficult to restrain.In the current scenario, this Research Topic aims to revise, analyze and compile the state of the art of the two most controversial issues about the herbicide glyphosate: its potential as an endocrine disrupting compound and as a probable human carcinogen. The present Research Topic includes different kinds of articles: an original article (Gorga et al.), two reviews (Milesi et al. and Romano et al.) and three mini-reviews (Anderson et al., Rodrı́guez et al. and Rossetti et al.). These articles describe different models of studies and possible targets of action of glyphosate herbicide which are closely related with female and male reproduction, reproductive outcomes, hormonal balance and the epigenome addressed by specialists in their fields.