Natural and semisynthetic compounds from Argentinean Polygonum acuminatum against human pathogenic yeasts

DI LIBERTO, M.; ZACCHINO, S.; DERITA, M.G.

Congreso; XXV SILAE Congress; 2016

In the last years, fungi have become the major cause of human infections, especially among immunocompromised hosts, having an enormous impact on morbidity and mortality. Although there are many available drugs for the treatment of systemic and superficial mycoses, they are not completely effective for their eradication. In addition, they all possess a certain degree of toxicity and quickly develop resistance due to inappropriate and abusive use. Therefore, there is an urgent need for the development of new antifungal chemical structures alternatives to the existing ones.1 In this context, exploring natural and semisynthetic products, turn out to be of great importance.